By sequencing a total of 2089 bp of the 16s rrna and phoe genes it was demonstrated that calymmatobacterium granulomatis the causative organism of donovanosis shows a high level of identity with klebsiella species pathogenic to humans klebsiella pneumoniae, klebsiella rhinoscleromatis. Biotinylated phoe pcr products obtained from 14 positive specimens from. Pdf culture of the causative organism of donovanosis. Granuloma inguinale donovanosis statpearls ncbi bookshelf. The infection has previously been known by other names, including granuloma inguinale tropicum, granuloma pudenda, granuloma venereum, and, most recently.
Free publisher full textpmc free full textpmc free pdf. Donovanosis is a chronic bacterial illness frequently associated with sexually transmitted infections sti and is. Definition of calymmatobacterium in the dictionary. May 15, 2006 no calymmatobacterium klebsiella granulomatis was detected in the study, but there were 3 detections during ongoing diagnostic use of gumpelaha in 2004 and 2005.
Meaning of calymmatobacterium granulomatis medical term. Development of a genital ulcer multiplex pcr cid 2006. Pubmed journal articles for calymmatobacterium granulomatis were found in prime pubmed. However, there is some debate about the classification of the causative organism. Dec 25, 2019 klebsiella granulomatis is gramnegative, rodshaped bacterium of the genus klebsiella known to cause the sexually transmitted disease granuloma inguinale or donovanosis. Donovanosis is a rare sexually transmitted infection now mainly seen in sporadic cases. Klebsiella granulomatis o calymmatobacterium granulomatis en bacteriologia en gefor. Files are available under licenses specified on their description page. Klebsiella granulomatis granuloma inguinale, donovanosis is a topic covered in the johns hopkins abx guide. Donovanosis or granuloma inguinale is a bacterial infection of the.
In this report, we present a case of a 50yearold man that was diagnosed with granuloma inguinale after a 2month history of a penile ulcer. Culture of the causative organism of donovanosis calymmatobacterium granulomatis in hep2 cells. Calymmatobacterium synonyms, calymmatobacterium pronunciation, calymmatobacterium translation, english dictionary definition of calymmatobacterium. Summary calymmatobacterium granulomatis is the aetiological agent of granuloma inguinale a chronic granulomatous genital infection and is morphologically similar to members of the genus klebsiella. Calymmataobacterium granulomatis klebsiela an intracellular organism which causes an ulcerating sexually transmitted infection, known as donovanosis or granuloma inguinale 1. Please help us continue to provide you with free, quality journalism by turning off your ad blocker on our site. Calymmatobacterium a genus of bacterial rods containing only the one species that causes granuloma. Whether youre a student, an educator, or a lifelong learner, can put you on the path to systematic vocabulary improvement. Jul 14, 2019 calymmataobacterium granulomatis klebsiela an intracellular organism which causes an ulcerating sexually transmitted infection, known as donovanosis or granuloma inguinale 1. We report successful culture of calymmatobacterium granulomatis by standard cell culture methods. Taxonomy of the species calymmatobacterium granulomatis.
Prime pubmed calymmatobacterium granulomatis journal articles. To incorporate the first polymerase chain reaction pcr assay for calymmatobacterium granulomatis into a colorimetric detection system for use in routine diagnostic laboratories. Donovanosis, a chronic cause of genital ulceration, has recently been the subject of. Granuloma inguinale is a chronic destructive granulomatous disease of the genitalia. Granuloma inguinale is treated with streptomycin or with broadspectrum antibiotics. What is donovanosis, a socalled flesh eating sexually.
Calymmatobacterium a genus of bacterial rods containing only the one species that causes granuloma inguinale genus calymmatobacterium bacteria. It is a stationary aerobic bacillus with nonsporulated capsule measuring 0. The cultivation from granuloma inguinale of a microorganism having the characteristics of donovan bodies in the yolk sac of chick embryos. Klebsiella granulomatis is gramnegative, rodshaped bacterium of the genus klebsiella known to cause the sexually transmitted disease granuloma inguinale or donovanosis. A colorimetric detection system for calymmatobacterium. For two patients, there was histological confirmation of the disease i. Biotinylated phoe pcr products obtained from 14 positive. The donovanosis is an infectious disease that merits diagnosis and appropriate treatment due to it has potential genital and extragenital complications that are considered side effect and could carry to. The clinical diagnosis is often unreliable and the definitive diagnosis is based on the visualisation of donovan bodies in tissue smears or biopsy specimens. Pdf donovanosis is a chronic bacterial illness frequently. Klebsiella granulomatis wikimili, the free encyclopedia wikimili, t.
Twentytwo biopsy specimens from female patients with clinical and laboratoryconfirmed granuloma inguinale were. Pmc free full textpmc free pdf cutaneous metastases of rectal mucinous adenocarcinoma mimicking granuloma inguinale. Doxycycline should be avoided in the second and third. Summary calymmatobacterium granulomatis is the aetiological agent of granuloma inguinale a. Klebsiella granulomatis granuloma inguinale infectious. Swabs were obtained from lesions in three patients with a clinical diagnosis of donovanosis. The infection has previously been known by other names, including granuloma inguinale tropicum, granuloma pudenda, granuloma venereum, and, most recently, granuloma inguinale. The causative organism, calymmatobacterium granulomatis, has been cultured for the first time in many years. Klebsiella granulomatis an overview sciencedirect topics. Mackay,1,2 gerry harnett,3 neisha jeoffreys,4 ivan bastian,5 kadaba s sriprakash,6 david siebert,7.
Sample conditionbased loinc and snomed encoding guidelines for reportable laboratory results. Proper usage and audio pronunciation of the word calymmatobacterium. Genital ulcers attributed to donovanosis were first described in india by. Other articles where calymmatobacterium granulomatis is discussed. The causative organism, calymmatobacterium granulomatis, has been cultured. Klebsiella granulomatis pdf granuloma inguinale is a genital ulcerative disease caused by the intracellular gramnegative bacterium klebsiella granulomatis formerly. Early aetiological diagnosis is of paramount importance so that development of genital elephantiasis can be prevented. It is also known as donovanosis, granuloma genitoinguinale, granuloma inguinale tropicum, granuloma venereum, granuloma venereum genitoinguinale, lupoid form of groin ulceration. Granuloma inguinale is a bacterial disease caused by klebsiella granulomatis formerly known as calymmatobacterium granulomatis characterized by genital ulcers. However, based on evidence of phylogenetic similarity with klebsiella species, a proposal was put forward that the organism be reclassi. Initial symptoms are painless papules that become ulcerated, ultimately forming granulomatous masses that tend to bleed easily. The ultrastructural features of cells of calymmatobacterium. Mackay im, harnett g, jeoffreys n, bastian i, sriprakash ks, siebert d, sloots tp.
Klebsiella granulomatis wikimili, the free encyclopedia. The intracellular organism responsible for granuloma inguinale was initially described by donovan over a century ago, and subsequently, the bacterium was classified in 19 as calymmatobacterium granulomatis. Comparison of culture with tissue biopsy specimens. The disease occurs rarely in the united states, although it is endemic in some tropical and developing areas, including india. Phylogenetic analysis of calymmatobacterium granulomatis based. Granuloma inguinale, or donovanosis, is a rare, sexually transmitted ulcerative disease primarily affecting the genital area. Culture of the causative organism of donovanosis calymmatobacterium granulomatis in hep2 cells article pdf available in journal of clinical microbiology 3511. Relapse can occur 618 months after apparently effective therapy. Klebsiella granulomatis formerly called calymmatobacterium granulomatis, a gramnegative bacillus, leads to donovanosis, a sexually transmitted genital ulcer disease. Although anderson suggested that the organism be eponymously named donovania granulomatosis, carter et al discovered that the molecular structure of the. Donovanosis, a chronic cause of genital ulceration, has recently been the subject of renewed interest after a long period of relative obscurity. Pdf culture of calymmatobacterium granulomatis researchgate. Jun 18, 2019 klebsiella granulomatis pdf granuloma inguinale is a genital ulcerative disease caused by the intracellular gramnegative bacterium klebsiella granulomatis formerly.
Donovanosis is a chronic, progressive ulcerative disease, usually of the genital region, that is caused by an encapsulated, gramnegative bacterium, klebsiella granulomatis, formerly known as calymmatobacterium granulomatis. Klebsiella granulomatis o calymmatobacterium granulomatis. Klebsiella granulomatis donovanosis, granuloma inguinale. Granuloma inguinale is caused by infection with calymmatobacterium granulomatis and occurs primarily in tropical and subtropical climates, including the southern united states. Calymmatobacterium definition of calymmatobacterium by. Genital elephantiasis is a disease that is characterized by massive enlargement of the genitalia.
Klebsiella granulomatis is an encapsulated, pleomorphic, gramnegative bacillus, measuring 1 to 2 m by 0. Apr 05, 2017 klebsiella granulomatis granuloma inguinale, donovanosis answers are found in the johns hopkins abx guide powered by unbound medicine. Jan 23, 2017 phylogenetic evidence for reclassification of calymmatobacterium granulomatis as klebsiella granulomatis comb. Calymmatobacterium granulomatis bacillum britannica. Mar 09, 2019 klebsiella granulomatis pdf granuloma inguinale is a genital ulcerative disease caused by the intracellular gramnegative bacterium klebsiella granulomatis formerly. It is rare in the united states and occurs primarily in the southern states. No calymmatobacteriumklebsiellagranulomatis was detected in the study, but there were 3 detections during ongoing diagnostic use of gumpelaha in 2004 and 2005. Calymmatobacterium granulomatis the free dictionary. Phylogenetic analysis of calymmatobacterium granulomatis. Phylogenetic evidence for reclassification of calymmatobacterium granulomatis as klebsiella granulomatis comb. Granuloma inguinale donovanosis 2015 std treatment. The causative organism formerly, calymmatobacterium granulomatis has recently. Although donovan bodies have been known to be associated with the disease since 1905, when donovan first described them, it was not until 1943 that it was clearly shown that the donovan bodies were bacterial in nature.
This study determined the 16s rrna gene sequence of c. Looking for online definition of calymmatobacterium granulomatis in the medical dictionary. Donovanosis granuloma inguinale online medical course. Ulcera genital por klebsiella granulomatis donovanosis. Calymmataobacterium granulomatis is an intracellular organism which causes an ulcerating sexually transmitted infection, known as donovanosis or granuloma inguinale. It was formerly called calymmatobacterium granulomatis. A read is counted each time someone views a publication summary such as the title, abstract, and list of authors, clicks on a figure, or views or downloads the fulltext. All structured data from the file and property namespaces is available under the creative commons cc0 license. For a complete taxonomy, refer to the taxonomic outline of bacteria and archaea, release 7.
Detection and discrimination of herpes simplex viruses, haemophilus ducreyi, treponema pallidum, and calymmatobacterium klebsiella granulomatis from genital ulcers. Donovanosis or granuloma inguinale is caused by infection with klebsiella granulomatis, formerly known as donovania granulomatis, and calymmatobacterium granulomatis, and was recently renamed following comparative dna sequencing studies. The causative organism, calymmatobacterium granulomatis, has been cultured for the first time in many years and a polymerase chain reaction diagnostic using a colorimetric detection system has been developed. Granuloma inguinale is a genital ulcerative disease caused by the intracellular gramnegative bacterium klebsiella granulomatis formerly known as calymmatobacterium granulomatis. The organism implicated in its aetiology, calymmatobacterium granulomatis, was reported to have been cultured 30 years ago, but little is known about the organism because of its fastidious nature and the difficulty in culturing it. European guideline for the management of donovanosis, 2010 free access.
Calymmatobacterium medical definition merriamwebster. The full text of this article is available as a pdf 434k. No calymmatobacterium klebsiella granulomatis was detected in the study, but there were 3 detections during ongoing diagnostic use of gumpelaha in 2004 and 2005. Calymmatobacterium granulomatis dictionary definition. Information about calymmatobacterium in the dictionary, synonyms and antonyms. Calymmatobacterium granulomatis synonyms, calymmatobacterium granulomatis pronunciation, calymmatobacterium granulomatis translation, english dictionary definition of calymmatobacterium granulomatis. Early aetiological diagnosis is of paramount importance so that development of genital elephantiasi. Apr 26, 2019 klebsiella granulomatis pdf granuloma inguinale is a genital ulcerative disease caused by the intracellular gramnegative bacterium klebsiella granulomatis formerly. Histological analysis demonstrated the presence of donovan bodies within macrophages, confirming the diagnosis. A capture oligonucleotide specific for the klebsiella phoe gene was covalently linked to tosyl activated magnetic beads. Klebsiella granulomatis wikipedia republished wiki 2. Pdf ultrastructure of calymmatobacterium granulomatis.
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